Nerlynx - Specialised Therapeutics

Adam M. Brufsky, MD, PhD Speaking at the Singapore Society of Oncology July 2022 on ‘Available Therapeutic Options for the Management of HER2-Positive Metastatic Breast Cancer: 2nd Line and Beyond’.

NALA was a multi-national, randomised, open-label Phase 3 trial of NERLYNX (neratinib)/capecitabine versus lapatinib/capecitabine in patients with HER2+ mBC who had received more than 2 prior lines of HER2-directed therapy.  Investigators found that the NERLYNX/capecitabine cohort had significantly improved PFS and importantly, there was a significant delay in the onset and progression of brain metastases

The Phase 2 CONTROL study is an international, open-label, sequential-cohort, Phase 2 study investigating the effects of loperamide prophylaxis alone or with add-on budesonide, a locally-acting corticosteroid used for inflammatory gastrointestinal conditions, or colestipol, a bile acid sequestrant, on NERLYNX-associated diarrhoea. Investigators have found that the addition of budesonide or colestipol to loperamide prophylaxis given

Patients whose adverse affects are appropriately managed and remain on NERLYNX for longer stand to gain the most benefit. That was the top-line message from a further analysis of the pivotal phase 3 ExteNET study, according to Puma Biotechnology Medical Director Dr Brian Barnett at ASCO 2018. Here he discusses the CONTROL study and optimal

NERLYNX and the Phase 3 ExteNET study were the focus of key presentations at ASCO 2018. New York Medical Oncologist Francis Arena MD provided the following insights. Watch the interview by clicking the link below.  

Breast cancer patients with HER2+/HR- tumours can still benefit from neratinib therapy, provided treatment is initiated within 6 months of trastuzumab therapy. We spoke with Dr Bent Ejlertsen from the Rigshospitalet, Copenhagen at ASCO 2018. Watch the interview by clicking the link below.